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Substance AbuseJanuary 7, 20215 min read

What Happens When You Mix Alcohol with Benzodiazepines

SOBA Recovery Team

Clinical Content Writer

Many people drink alcohol after taking a drug in order to enhance the substance's effects but doing so can be incredibly dangerous. Combining alcohol with benzodiazepines is particularly risky because both substances slow activity in the central nervous system which can cause difficulty breathing, blackouts, coma, and an increased risk of overdose. Here's what you should know about the two substances and what can happen when they're consumed together.

The Effects of Benzodiazepines

Benzodiazepines are medications used to treat anxiety disorders, nervousness, seizures, muscle spasms, and sleep issues. Benzodiazepines also called "benzos," act as a sedative by increasing and mimicking the effect of GABA, a brain chemical that reduces activity in the central nervous system, evoking a drowsy, calm, and relaxed feeling. Unfortunately, these medicines, which include Valium, Xanax, Halcion, Ativan, and Klonopin, can be habit-forming, which can, in turn, lead to dependence, abuse, and addiction. When combined with alcohol, benzodiazepines can become even more dangerous.

The Dangers of Mixing Alcohol with Benzos

Both alcohol and benzodiazepines can harm the body, but the damage increases when the two substances are combined. As depressants, both alcohol and benzodiazepines diminish activity in the central system. When taken together, the substances greatly diminish users' nervous system activity, which can cause a number of harmful side effects, including:

  • Slowed, labored, breathing
  • Weakened immune system
  • Unconsciousness
  • Organ failure
  • Coma

Mixing alcohol with benzodiazepines can also cause:

  • Cognitive Impairments. Individuals who mix alcohol and benzos typically experience a significant reduction in their cognitive functioning. With the activity in the central nervous system slowed down, cognitive functions like thinking, reasoning, and controlling emotions can become impaired. Large quantities of alcohol and benzodiazepines can slow the flow of oxygen so much that individuals faint or blackout.
  • Long-term Physical Conditions. Consuming alcohol with benzodiazepines can seriously weaken individuals' immune systems. This makes users more likely to experience physical health conditions such as liver and kidney damage. Cardiovascular and gastrointestinal issues are also commonly associated with alcohol and benzodiazepine use. Prolonged alcohol and benzodiazepine use can cause neurological issues that can potentially lead to dementia.
  • Mental Health Disorders. Researchers have discovered that combining alcohol and benzodiazepines can increase users' risk of developing mental health disorders. The enhanced effects, combined with diminished activity in the nervous system, can lead to depression, bipolar disorder, anxiety disorders, psychosis, and trauma and stress-related disorders. Suicidal thoughts are often common side effects of poly-drug and multi-depressant use.
  • Overdose. Mixing two central nervous system depressants increases your overdose risk for one or both substances. The presence of benzodiazepines reduces the amount of alcohol that can lead to an overdose. Similarly, consuming alcohol reduces the dosage of benzodiazepines that can cause an overdose. In addition to that, the body metabolizes alcohol faster than any other addictive substance. This means benzodiazepines remain in individuals' systems longer when users take the two substances together, increasing the likelihood of adverse effects and overdose.

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Frequently Asked Questions

What happens when you mix alcohol and benzodiazepines?

Both substances are central nervous system depressants, so together they slow the body down far more than either would alone. The combination can cause slowed or labored breathing, severe drowsiness, impaired thinking, blackouts, unconsciousness, and in serious cases organ failure or coma.

Why does mixing alcohol and benzos increase overdose risk?

Each substance lowers the amount of the other needed to cause an overdose—benzodiazepines reduce how much alcohol is dangerous, and alcohol reduces how many benzodiazepines are dangerous. On top of that, the body metabolizes alcohol first, which keeps benzodiazepines in your system longer and raises the risk of adverse effects.

What are the signs of an alcohol and benzodiazepine overdose?

Watch for extreme drowsiness or unresponsiveness, slow or shallow breathing, confusion, limpness, and bluish lips or fingertips. An overdose involving two depressants can turn fatal quickly—if you suspect one, call 911 immediately and stay with the person until help arrives.

Is it safe to drink alcohol while prescribed a benzodiazepine?

No—doctors advise against drinking while taking benzodiazepines like Xanax, Valium, Ativan, or Klonopin. Some benzodiazepines stay in your system for days, so the two substances can interact even when they aren't taken at the same time. If you find it hard to avoid alcohol while on a benzodiazepine, talk to your prescriber.

How do you treat dependence on both alcohol and benzodiazepines?

Withdrawal from alcohol and benzodiazepines can each be dangerous on their own, and quitting both at once should never be attempted cold turkey. A medically supervised detox keeps the process safe, and a benzodiazepine treatment program can then address the underlying dependence on both substances.

Tags:Substance AbuseAlcoholBenzodiazepinesTreatmentAddiction

About the Author

SOBA Recovery Clinical Team

Our clinical content is written and reviewed by addiction specialists, therapists, and healthcare professionals with extensive experience in treating substance use disorders.

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